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NMN 98% Capsules

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NMN 98% Capsules

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Scientific Studies

Several studies have investigated the effects of NMN. They have indicated that a dose of 500mg of NMN is the most effective without any adverse side effects. We have summarised the most interesting results from rodent studies and clinical trials.

Study 1

Study type: 

Randomised, double-blind, placebo-controlled, parallel-group trial

Purpose:

To evaluate whether chronic NMN supplementation elevates blood NAD+ levels and affects physiological dysfunctions in healthy older participants. NAD+ is a critical molecule that supports energy production, DNA repair, and cellular communication. 

NMN dose:

250 mg/day or a placebo

Duration:

6 or 12 weeks

Participants: 

42 men aged over 65 years

Results:

Long-term NMN supplementation was well tolerated and caused no significant adverse effects. Blood analyses revealed significant increases in NAD+ and its related metabolites concentrations, which play crucial roles in processes associated with energy production and tissue repair Research has found that NAD+ levels naturally decline with age, and an increase in NAD+ may enhance energy metabolism, support cell and tissue repair, and contribute to overall well-being.

The researchers observed significant improvements in muscle performance like grip strength and walking speed. It is worth noting that reductions in strength are a clinical indicator of ageing.

The authors concluded that long-term NMN supplementation may be used to boost NAD+ for preventing age-related muscle dysfunctions in humans.

Year:

2022

Link:

https://doi.org/10.1038/s41514-022-00084-z 

Study 2

Study type: 

Animal study (mice)

Purpose:

To investigate the long-term effects of NMN administration on age-associated physiological decline in mice.

Age-related complication:

Age-associated physiological decline

NMN dose:

100 and 300 mg/kg for 12 months 

Duration:

12 months

Results:

The study found that orally administered NMN was quickly absorbed, efficiently transported into blood circulation, and immediately converted to NAD+ in major metabolic tissues (tissues are groups of similar cells that work together to perform a specific function in the body). NAD+ is a crucial coenzyme involved in various cellular processes, including energy production, DNA repair, and cell signalling.

In addition, the study found that NMN suppressed age-associated body weight gain and enhanced energy metabolism, improved insulin sensitivity, eye function, and other features with no toxic effects. NMN also prevented age-associated gene expression changes. This means that NMN  may have the ability to counteract or prevent the alterations in gene activity that typically occur as a result of ageing.

These effects indicate that NMN (and other NAD+ intermediates) may be an effective anti-ageing intervention in humans, although clinical studies are required.

Year

2016

Link:

https://doi.org/10.1016/j.cmet.2016.09.013 

Study 3

Study type: 

Animal study (aged mice)

Purpose:

To investigate the effects of NMN supplementation on blood vessel dysfunction (a condition where the inner lining of blood vessels does not function properly) and oxidative stress (an imbalance between harmful molecules called free radicals and antioxidants in the body), which are both associated with ageing and contribute to an increased risk of cardiovascular diseases, impaired cellular function, chronic inflammation, and accelerated ageing.

Age-related complication:

Age-associated vascular dysfunction and oxidative stress

NMN dose:

300 mg/kg body weight/day in drinking water or a control (just drinking water)

Duration:

8 weeks

Results:

8 weeks of NMN supplementation restored a marker of arterial sirtuin activity. Sirtuins are proteins that are known to have protective effects on blood vessels and promote healthy ageing. NMN also improved age-associated blood vessel dysfunction and artery stiffening. Artery stiffening refers to the loss of flexibility and increased rigidity of blood vessel walls, which can lead to reduced blood flow, elevated blood pressure, and an increased risk of cardiovascular diseases.

These improvements were associated with restored nitric oxide, a molecule that plays a crucial role in regulating blood vessel function, as well as the either complete or partial normalisation of structural proteins in the arterial wall and a reduction of vascular oxidative stress, which is important for maintaining the health and function of blood vessels and reducing the risk of related diseases. 

The results provide evidence that oral supplementation with NMN may restore SIRT1 activity (a sirtuin gene) and potentially combat or reverse age-related arterial dysfunction by decreasing oxidative stress.

Year

2016

Link:

https://doi.org/10.1111/acel.12461 

Study 4

Study type: 

Animal study (aged mice) 

Age-related complication:

Age-associated decline in DNA repair 

NMN dose:

500 mg/kg body weight/day

Duration:

7 days

Results:

NMN treatment reduced DNA damage and protected against changes in haemoglobin, a protein found in red blood cells that plays a crucial role in transporting oxygen from the lungs to the body's tissues and organs. NMN also protected against changes in white blood cell count (including lymphocytes). Reducing DNA damage and maintaining stable haemoglobin and white blood cell levels contribute to better cellular health, improved oxygen transport, and a well-functioning immune system. These factors collectively support overall health and reduce the risk of various age-related diseases and health complications.

Year

2017

Link:

https://doi.org/10.1126/science.aad8242

Study 5

Study type: 

Animal study (rats)

Purpose:

To compare NMN with nicotinamide (vitamin B3) as a superior precursor of NAD in mice. NAD plays a vital role in supporting mitochondrial function for cellular energy production, but its levels decrease with age, affecting energy production, DNA repair, and essential processes. Maintaining healthy NAD levels may help mitigate some of the effects of ageing.

NMN dose:

45 μmol//kg body weight injected intraperitoneally (single dose)

Results:

Compared to nicotinamide, NMN resulted in a higher increase in NAD+, activated a higher response of SIRT1 (a sirtuin gene linked to healthy ageing) and had greater anti-aging activity.

These findings may indicate enhanced energy production, improved DNA repair, better cellular health, and potentially slowing down of the ageing process.

Year

2016

Link:

https://doi.org/10.3177/jnsv.62.272 

Study 6

Study type: 

Animal study (aged mice) 

Purpose:

In mice supplemented with NMN, researchers assessed the role of NAD+ (a critical molecule for cellular functions)  and SIRT1 (a protein known as a sirtuin, which is involved in regulating cellular processes related to ageing and relies on NAD for its activity) in acute kidney injury susceptibility. NMN is known as the building block for NAD.

Age-related complication:

Age-associated susceptibility to acute kidney injury

NMN dose:

500 mg/kg body weight/day (intraperitoneal)

Duration:

4 days

Results:

NMN supplementation increased NAD+ levels (an important molecule for energy production, DNA repair, and cell signalling) in aged kidneys. This increase in NAD+ levels was also associated with increased activity of SIRT1 (a protective protein), and protected aged kidneys from both ischemia–reperfusion (reduced blood flow) and chemotherapy-related kidney injuries.

Year

2017

Link:

https://doi.org/10.1681/ASN.2016040385

Study 7

Study type: 

Animal study (aged mice) 

Purpose:

To explore the potential of NMN in restoring capillary density and improving endurance in old mice. Capillaries are the smallest blood vessels in the body. Capillary density is important for the exchange of oxygen, nutrients, and waste products between the blood and tissues. 

Age-related complication:

Blood vessel ageing

NMN dose:

400 mg/kg body weight/day (in drinking water)

Duration:

2 months

Results:

NMN improved blood flow by restoring the capillary density (the number of tiny blood vessels) of elderly mice to youthful levels. Capillary density is important for various physiological processes, including tissue growth, repair, and metabolism. NMN also improved the treadmill endurance of old mice towards youthful levels.

Year

2018

Link:

https://doi.org/10.1016/j.cell.2018.02.008

Study 1

Study type: 

Randomised, multicentre, double-blind, placebo-controlled, parallel group, dose-dependent trial

Purpose:

The primary objective was to evaluate blood concentrations of nicotinamide adenine dinucleotide (NAD) with different doses of NMN. NAD is a vital molecule that acts like a helper in the body's cells, participating in important processes like turning food into energy and helping to repair damaged DNA.  The secondary objectives were to assess the safety, tolerability and clinical efficacy of NMN supplementation.

Measurement methods:

Clinical efficacy was evaluated by conducting a subjective general health assessment (survey) and measuring NAD blood concentration, physical performance (six-minute walking test), blood biological age (Aging.Ai 3.0 calculator) and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). The HOMA-IR calculation involves analysing fasting blood glucose and insulin levels to provide an estimate of insulin resistance. 

NMN dose:

300, 600 or 900 mg/day, or a placebo

Duration:

60 days

Participants:

80 middle-aged healthy adults

Results:

Compared to the placebo, the blood concentration of NAD significantly improved as the NMN dose increased (dose-dependent). An increase in NAD+ may enhance energy metabolism, support cell and tissue repair, and contribute to overall well-being. Research has found that NAD+ levels naturally decline with age. The most beneficial effects in the study, particularly on blood NAD levels and physical performance, were achieved with a daily oral intake of 600 mg.  Oral administration of NMN up to 900 mg/day for 60 days was safe and well tolerated. The 900 mg/day oral dose did not have significantly better efficacy than the 600 mg/day dose. 

In addition, the study found an association between NMN supplementation and improvements in physical endurance and general health conditions, as evidenced by significant improvements in measures such as the six-minute walking test, blood biological age, and general health survey when compared to a placebo. Overall, these findings suggest that NMN supplementation may improve health and physical performance.

Year:

2022

Link:

https://doi.org/10.1007/s11357-022-00705-1

Study 2

Study type: 

Randomised, double-blind, placebo-controlled, parallel-group trial

Purpose:

To investigate the influence of 12-week NMN supplementation on biochemical and metabolic health parameters.

NMN dose:

250 mg/day (2 x 125 mg/day) or a placebo

Duration:

12 weeks

Participants: 

36 healthy, middle-aged men and women

Results:

The researchers observed that serum nicotinamide (NAD+) levels were significantly higher in the NMN intake group than in the placebo group. Nicotinamide is a form of vitamin B3 and a building block for NAD+, which plays a critical role in cellular energy production and other cellular processes. Low levels of nicotinamide in the blood may indicate a vitamin B3 deficiency, potentially impacting various aspects of health, as NAD+ is involved in many vital processes within the cells. 

NMN supplementation showed potential in reducing arterial stiffness as indicated by a tendency of pulse wave velocity values, a measure of arterial stiffness, to decrease in the NMN group. Stiff arteries hinder blood flow, which can increase the risk of heart-related problems. However, no significant difference was found between the NMN and placebo groups. 

Long-term NMN supplementation at 250 mg/day was well tolerated and did not cause adverse events. NMN safely and effectively elevated NAD+ metabolism in healthy middle-aged adults.  

Year:

2023

Link:

https://doi.org/10.1038/s41598-023-29787-3

Study 1

Study type: 

Randomised double-blind placebo-controlled trial

Purpose:

To investigate the effect of NMN supplementation on metabolic function in postmenopausal women with prediabetes who are overweight or obese

NMN dose:

250 mg/day or placebo

Duration:

10 weeks

Participants:

25 postmenopausal women with prediabetes

Results:

The study found an association between NMN supplementation and increased muscle insulin signalling, which involves the phosphorylation (activation) of certain proteins such as protein kinase AKT and the targeting of rapamycin (mTOR), compared to the placebo group. These proteins work together and are crucial for maintaining proper blood sugar levels and ensuring the muscles have the energy they need to function effectively. 

In addition, NMN supplementation was associated with increased muscle insulin sensitivity, indicating that the muscles became more responsive to the effects of insulin, a crucial factor for managing blood sugar levels and overall metabolic well-being. This improvement was measured by how quickly glucose was removed per unit of fat-free mass.

Year:

2021

Link:

https://doi.org/10.1126/science.abe9985

Study 2

Study type: 

Animal study (age-induced and diet-induced diabetic mice)

Purpose:

To investigate whether NMN could help treat diabetes caused by diet and ageing in mice.

Age-related complication:

Age- and diet-induced diabetes

NMN dose:

500 mg/kg body weight/day intraperitoneally for 7–10 days

Results:

Researchers observed several positive effects of NMN in mice with type 2 diabetes. Firstly, NMN improved glucose and lipid metabolism, specifically enhancing insulin secretion, insulin sensitivity, lipid profile, hepatic insulin sensitivity, and glucose tolerance.  Improvements in these factors collectively contribute to maintaining healthy blood sugar levels, efficient energy metabolism, and overall cardiovascular health. When these aspects are functioning optimally, the risk of chronic diseases such as type 2 diabetes and cardiovascular diseases is lowered. 

Secondly, NMN restored NAD+ levels (a molecule involved in energy metabolism) in the liver and body fat. Elevated NAD+ levels are generally associated with improved cellular health, enhanced metabolism, and potential benefits for longevity and overall well-being.

Thirdly, NMN normalised the inflammatory response, circadian rhythm (the body's internal clock that regulates sleep and other functions) and oxidative stress (cell damage caused by harmful molecules) affected by high-fat diets and ageing. These improvements were partly attributed to increased NAD+ levels and the activation of SIRT1, a protein associated with metabolic regulation and longevity.

The results provide evidence that promoting NAD+ biosynthesis by administering NMN may be an effective intervention to treat the pathophysiology of diet- and age-induced type 2 diabetes. 

Year

2011

Link:

https://doi.org/10.1016/j.cmet.2011.08.014 

Study 1

Study type: 

Animal (rats) and cellular study 

Purpose:

To study the impact of NMN on beta-amyloid oligomer-induced neuronal death and cognitive impairment.  These oligomers are considered to be toxic and are thought to play a significant role in the development and progression of Alzheimer's disease.

Age-related complication:

Alzheimer's disease

NMN dose:

500 mg/kg body weight/day

Duration:

10 days

Results:

NMN improved cognitive function, neuron survival and energy metabolism. These improvements potentially slow down the progression of cognitive decline. NMN restored levels of NAD+ (a key player in energy metabolism, DNA repair, and cell signalling) and ATP (the cell's primary energy currency) and eliminated the accumulation of reactive oxygen species (ROS), which are harmful molecules that can cause damage to cells and DNA This restoration of NAD+ and ATP levels and reduction in ROS accumulation is beneficial because it can potentially support better cellular energy production, protect neurons from oxidative stress, and contribute to the overall health of brain cells. This is particularly important in the context of Alzheimer's disease, where cellular dysfunction and oxidative damage contribute to the disease's progression.

Year

2016

Link:

https://doi.org/10.1016/j.brainres.2016.04.060

Study 2

Study type: 

Animal study (a mice model of Alzheimer’s disease)

Purpose:

To investigate the effect of NMN on brain mitochondrial impairments. Mitochondria are the energy-producing "powerhouses" of our cells.

Age-related complication under study:

Alzheimer’s disease

NMN dose:

100 mg/kg body weight subcutaneously every other day for 28 days

Duration:

28 days

Results:

Researchers observed improvements in the functioning of mitochondria, the energy-producing “powerhouses” of cells. In Alzheimer’s disease, there are known issues with the functioning of mitochondria. There was also a reduction in mutant amyloid precursor proteins, which may potentially slow down or prevent the progression of Alzheimer's disease.

NMN treatment also increased the levels of SIRT1 and CD38, which are proteins that play important roles in cellular processes that normally decline with age.  

Year

2015

Link:

https://doi.org/10.1186/s12883-015-0272-x 

Study 3

Study type: 

Animal study (mice) 

Purpose:

To investigate the effects of NMN and its underlying mechanisms in mice with Alzheimer's disease.

Age-related complication:

Alzheimer’s disease

NMN dose:

100 mg/kg body weight/every other day (subcutaneously)

Duration:

28 days

Results:

NMN substantially improved cognitive impairments, neuroinflammation, beta-amyloid pathology and synaptic loss. Both beta-amyloid pathology (plaques) and synaptic loss are key features of Alzheimer's disease and are associated with cognitive decline and memory problems characteristic of the condition.

Year

2017

Link:

https://doi.org/10.1016/j.neulet.2017.03.027

Study 4

Study type: 

Animal study (aged rats) 

Purpose:

To investigate the effect of NMN on cognitive outcomes in aged rats.

Age-related complication:

Cognitive impairment due to ageing

NMN dose:

100 mg/kg body weight/ every other day

Duration:

28 days

Results:

NMN had neuroprotective effects, reduced cognitive decline and helped improve age-associated memory and learning impairments.

Year

2019

Link:

https://doi.org/10.1016/j.neuroscience.2019.09.037

Study 1

Study type: 

Randomised double-blind placebo-controlled trial

NMN dose:

There were 3 different dosage groups and a placebo group:

  1. 300 mg/day (low dosage group)
  2. 600 mg/day (medium dosage group)  
  3. 1200 mg/day (high dosage group)

Each group consisted of 10 male participants and 2 female participants. 

Additional interventions:

All participants actively trained during the study period by adhering to an exercise program: 6 weeks of aerobic exercise (running and cycling), with 5–6 sessions per week lasting 40–60 min each. 

Participants:

48 young and middle-aged recreational runners

Duration:

6 weeks

Results:

The researchers observed significant improvements in aerobic capacity (a measure of the body's ability to take in, transport, and utilise oxygen during sustained physical activity) and the endurance of amateur runners during exercise training after NMN supplementation, when compared to the placebo group. These improvements were dose dependent, meaning that the higher the NMN dose, the greater the effect on aerobic capacity and endurance. The authors attribute this improvement to enhanced oxygen utilisation in skeletal muscles. The moderate and higher doses were associated with greater improvements in aerobic capacity than the lower dose. 

Year:

2021

Link:

https://doi.org/10.1186/s12970-021-00442-4 

Study 2

Study type: 

Randomised double-blind placebo-controlled trial

Purpose:

To investigate the effects of the time-dependent intake of nicotinamide mononucleotide (NMN) on sleep quality, fatigue, and physical performance in older adults.

NMN dosage:

250 mg or a placebo either in the morning or in the evening to compare the effect of intake at different times.

Duration:

12 weeks

Participants: 

108 

Results:

The participants in the study reported reduced drowsiness after NMN supplementation. The study also revealed an association between NMN intake in the afternoon and significant improvements in lower body strength, balance, and functional mobility (the ability to move and perform daily tasks without difficulty). Overall, the authors concluded that NMN may have the potential to improve fatigue and prevent the loss of physical performance.

Year:

2022

Link:

https://doi.org/10.3390/nu14040755

 

Study 1

Study type: 

Randomised, double blind, parallel-group trial 

Purpose:

To investigate the safety of orally administered NMN and its efficacy to increase NAD+ levels.

NMN dose:

250 mg/day or a placebo

Duration:

12 weeks

Participants: 

30 healthy subjects 

Results:

Oral supplementation of NMN for 12 weeks caused no abnormalities in physiological and laboratory tests, and no obvious adverse effects were observed. NAD+ levels in whole blood were significantly increased after NMN administration.  NAD+ plays a vital role in multiple cellular processes, and an increase in its levels suggests that the body has additional support for these vital processes, potentially resulting in favourable impacts on overall health and well-being. The authors concluded that oral administration of NMN may be a safe and practical strategy to boost NAD+ levels in humans.

Year:

2022

Link:

https://doi.org/10.3389/fnut.2022.868640

Study 2

Study type: 

Randomised, double-blind, placebo-controlled, parallel-group trial

Purpose:

To evaluate the safety of 1250mg of β-NMN administered orally once daily. 

NMN dose:

1250 mg/day or a placebo

Duration:

4 weeks

Participants: 

31 healthy adult men and women aged 20-65

Results:

The researchers observed that oral administration of 1250 mg of NMN once daily for 4 weeks did not result in any severe adverse events during the study period. The findings suggest that NMN is safe and well-tolerated in healthy adults.

Year:

2022

Link:

https://doi.org/10.1038/s41598-022-18272-y

Study 3

Study type: 

Uncontrolled exploratory trial

Purpose:

To verify the safety of NMN administered through human veins.

NMN dose:

300 mg dissolved in 100mL of salt solution

Duration:

12 weeks

Participants: 

5 males and 5 females (aged 20-70)

Results:

The study found an association between intravenous NMN administration and increased blood NAD+, a vital molecule that helps keep proper cell functioning and supports various aspects of overall health, without damaging blood cells.

Researchers also observed that NMN did not affect the participants’ heart's electrical activity, pulse, or blood pressure. It also did not impact metabolic markers in the liver, heart, pancreas, and kidneys. Additionally, the researchers noted a reduction in blood triglyceride (fat) levels after NMN administration. Elevated triglyceride levels have been linked to an increased risk of heart disease and other health issues. Intravenous administration normally carries a higher risk of damaging major organs compared to oral administration. This is because nutrients and drugs administered intravenously circulate directly in the blood without going through the liver, the body's centre for detoxification. 

These findings indicate that intravenous NMN administration is not only safe but also potentially beneficial for humans.

Year:

2022

Link:

https://doi.org/10.7759/cureus.28812

Study 4

Study type: 

Uncontrolled trial

Purpose:

To investigate the safety of single NMN administration in 10 healthy men

NMN dose:

100, 250, and 500 mg (single administrations)

Duration:

Acute (5 hours)

Results:

The study found an association between NMN administration and a significant increase in the levels of NMN metabolites, the chemical compounds produced as a result of the metabolic processes of NMN. Previous research has already demonstrated a positive correlation between changes in NMN metabolite levels and changes in NAD+, a crucial component in cell functions such as energy production and DNA repair. Therefore, an increase in these NMN metabolites may indicate an elevation in NAD+ levels, potentially benefiting overall health and addressing age-related concerns.

In addition, a single oral administration of NMN up to 500 mg was safe and well-tolerated in healthy men. No significant adverse effects were observed. The authors concluded that oral administration of NMN is feasible and could be used as a potential therapeutic strategy to replenish cellular NAD+ levels to mitigate age-related functional disorders in humans.

Year:

2020

Link:

https://doi.org/10.1507/endocrj.EJ19-0313 

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How to use

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    One Capsule Per Day

    Take one 500mg capsule daily, ideally in the morning.

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    With or Without Food

    NMN can be taken with food or on an empty stomach. However, the impact of food on supplement absorption is often unpredictable as different compounds within food can interact with the supplement in different ways.

    On the other hand, taking NMN with food will slow absorption, which can be beneficial if you want the effects to kick in slower or if you experience nausea when taking the supplement on an empty stomach.

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Customer Reviews

Based on 63 reviews
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O
Owen Foster

Very good customer service. Had to contact Natural Foundation and had a very quick response. Early days with the supplements, I have only been taking them a couple of weeks. I'm quite optimistic though. No negative reaction to the collagen powder. It contains fish in the ingredient which can prompt an adverse reaction but it's been fine. I put it in a blackcurrant cordial and I wouldn't know it's in the glass.

R
Robert Helbert

Still too soon to give informed review

R
RICHARD CARLSON
Anti-aging review

Take it every day. I fell and look younger. Probably should stay on it for a bit longer to get a more precise analysis.

S
Scott Hawkins

Great

h
hayley scott
Great product

On my second bag - I have seen an improvement in my fine lines. I am 51 and doing all I can to support my skin. Taste is pleasant and I add to my protein drink

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Frequently Asked Questions

  • Why not just take an NAD+ supplement rather than NMN to increase NAD+ levels?

    On the surface, it may seem more logical to simply take an NAD+ supplement. However, NAD+ cannot readily cross cell membranes to enter cells. Precursor molecules like NMN are more bioavailable, meaning they can be absorbed easier and are more effective at increasing NAD+ levels than simply taking an NAD+ supplement.

  • Are there any side effects?

    Clinical trials have shown no adverse side effects at 500 mg/day. We go through great trouble and research to ensure our dosages are as safe and effective as possible. Do not exceed 1200 mg/day.

  • What is NMN?

    NMN stands for nicotinamide mononucleotide. It is a naturally occurring molecule in the body called a nucleotide.

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